Transgenic overexpression of toxin-related ecto-ADP-ribosyltransferase ART2.2 sensitizes T cells but not B cells to NAD-induced cell death

► The cell surface ADP-ribosyltransferase ART2 was overexpressed in transgenic mice. ► The H2k promoter drives ART2 expression on 80% of T cells but only on 20% of B cells. ► High levels of ART2 on transgenic T and B cells correlate with high ART activity. ► ART2-transgenic T cells but not B cells are sensitive to NAD-induced cell death.