کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5917846 | 1570735 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Short communicationMannan-binding lectin-2 (MBL2) gene polymorphisms in prenatal and perinatal cytomegalovirus infections Short communicationMannan-binding lectin-2 (MBL2) gene polymorphisms in prenatal and perinatal cytomegalovirus infections](/preview/png/5917846.png)
Cytomegalovirus (CMV) is the leading cause of congenital infections among neonates. About 10% of newborns with such an infection have clinical symptoms at birth and about 1% of infected fetuses die due to developmental malformations. Mannan-binding lectin (MBL) is considered to be an important factor in innate immunity. Its deficiency is believed to predispose to various (including viral) infections. The aim of this study was to investigate the possible role of MBL2 gene polymorphisms in prenatal and perinatal CMV infections. The frequencies of MBL2 gene exon 1 mutations as well as MBL deficiency-associated variants (LXPA/OÂ +Â O/O) among newborns with confirmed cytomegalovirus infection were not significantly lower than among non-infected individuals. The distribution of MBL2 haplotypes was similar between the groups studied. These data suggest MBL does not have a major influence on susceptibility to prenatal or perinatal CMV infections.
⺠This is the first report concerning MBL in pre- and perinatal CMV infections. ⺠We compared the frequencies of MBL2 gene mutations between CMV-infected and non-infected newborns. ⺠No significant differences were found. ⺠The distribution of MBL2 haplotypes was similar between the groups studied.
Journal: Molecular Immunology - Volume 48, Issues 15â16, September 2011, Pages 2203-2206