کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5917970 | 1163816 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thymic cysts originate from Foxn1 positive thymic medullary epithelium
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کلمات کلیدی
Three-dimensionalFTOCTECsmTECscTECsdGuoFOXN1DPC5-bromodeoxyuridineBrdU - بروموداکسی اوریدینtwo-dimensional - دو بعدیembryonic day - روز جنینیThymic epithelial cells - سلول های اپیتلیال ThymicMedullary thymic epithelial cells - سلول های اپیتلیال سمیوم مدولارcortical thymic epithelial cells - سلولهای اپیتلیال تومور کورتونیFetal thymic organ culture - فرهنگ ارگانیک جنینkeratin 5 - کراتین 5keratin 8 - کراتین 8Thymic cysts - کیست تیمیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Thymic epithelial cells (TECs), derived from polarized two-dimensional (2D) oriented endodermal cells, are distinguished from other epithelial cells by their unique three-dimensional (3D) phenotype. However, some polarized epithelial cells remain present in the normal thymus, forming thymic cysts at the cortico-medullary junction. Here, we analyse the dynamics, origin and phenotype of such thymic cysts. In time-course experiments, we show a reverse correlation between thymic cyst expansion and the presence of thymocytes, suggesting a default pathway for the development of TECs in the absence of thymocytes. By transplanting isolated TEC populations into E15 fetal thymic lobes, we provide evidence that medullary thymic epithelial cells (mTECs), rather than cortical thymic epithelial cells (cTECs) contribute to the formation of thymic cysts. Finally, thymi of reporter mice reveal that the cysts originate from epithelia committed to a thymic fate, as indicated by the expression of Foxn1. The 2D-phenotype of cyst-lining TECs is not caused by a downregulation of Foxn1 expression, since a significant proportion of these cells in the embryonic and adult thymus continues to express Foxn1 at the protein level.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 47, Issue 5, February 2010, Pages 1106-1113
Journal: Molecular Immunology - Volume 47, Issue 5, February 2010, Pages 1106-1113
نویسندگان
Eric Vroegindeweij, Stijn Crobach, Manami Itoi, Rumi Satoh, Saulius Zuklys, Christiane Happe, Wilfred T.V. Germeraad, Jan J. Cornelissen, Tom Cupedo, Georg A. Holländer, Hiroshi Kawamoto, Willem van Ewijk,