کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5920671 | 1164301 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Modular organizations of novel cetacean papillomaviruses Modular organizations of novel cetacean papillomaviruses](/preview/png/5920671.png)
The phylogenetic position of cetacean papillomaviruses (PVs: Omikron-PVs and Upsilon-PVs) varies depending on the region of the genome analysed. They cluster together with Alpha-PVs when analysing early genes and with Xi-PVs and Phi-PVs when analysing late genes. We cloned and sequenced the complete genomes of five novel PVs, sampled from genital and oesophageal lesions of free-ranging cetaceans: Delphinus delphis (DdPV1), Lagenorhynchus acutus (TtPV3 variant), and Phocoena phocoena (PphPV1, PphPV2, and PphPV3). Using Maximum Likelihood and Bayesian approaches, all cetacean PVs constituted a monophyletic group with Alpha-, Omega-, and Dyodelta-PVs as inferred from E1-E2 early genes analyses, thus matching the shared phenotype of mucosal tropism. However, cetacean PVs, with the exception of PphPV3, were the closest relatives of Xi-PVs and Phi-PVs in L2-L1 late genes analyses, isolated from cow and goat, thus reflecting the close relationship between Cetacea and Artiodactyla. Our results are compatible with a recombination between ancestral PVs infecting the Cetartiodactyla lineage. Our study supports a complex evolutionary scenario with multiple driving forces for PV diversification, possibly including recombination and also interspecies transmission.
Research highlights⺠Five novel PV sequences from genital and oesophageal lesions of free-ranging cetaceans. ⺠PV evolution in early genes correspond to the shared phenotype of mucosal tropism. ⺠PV evolution in late genes reflects the close relationship between Cetacea and Artiodactyla. ⺠PphPV3 may represent a relative of a donor of genetic elements to the remainders of extant cetacean PVs. ⺠Complex evolutionary scenario with multiple driving forces for PV diversification
Journal: Molecular Phylogenetics and Evolution - Volume 59, Issue 1, April 2011, Pages 34-42