Neuroprotective effect of geraniol and curcumin in an acrylamide model of neurotoxicity in Drosophila melanogaster: Relevance to neuropathy

- Geraniol (Ger) and curcumin (Cur) significantly offset ACR-induced lethality.
- Ger/Cur markedly improve ACR-induced locomotor deficits in flies.
- Ger/Cur attenuate oxidative stress in cytosol and mitochondria.
- Ger/Cur restore cholinergic function (AChE activity) and dopamine levels.
- Neuroprotective effect is mediated by enhanced levels of GSH/antioxidant enzymes.