کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5923369 | 1571166 | 2015 | 7 صفحه PDF | دانلود رایگان |

- Peromyscus californicus mice were housed in isolation for 4 or 24Â days.
- Male mice isolated for 4Â days increased cell proliferation in the hippocampus.
- Female mice isolated for 24Â days increased cell survival in the hippocampus.
- Results indicate sex and species specific cellular patterns following isolation.
Social environment has direct effects on an animal's behavior, physiology and neurobiology. In particular, adult neurogenesis is notably affected by a variety of social manipulations, including social isolation. We hypothesized that social isolation should have particularly acute effects on neurogenesis in a highly social (monogamous and bi-parental) species such as Peromyscus californicus, the California mouse. Adult male and female P.californicus mice were housed in isolation or in same-sex pairs for 4 or 24Â days. At the end of each period, either cell proliferation or cell survival was quantified with BrdU label and neuronal markers (either TuJ1 or NeuN). After 4Â days, isolated males had greater cellular proliferation in the dentate gyrus of the hippocampus (DG) than pair housed males. After 24Â days, isolate females demonstrated greater cell survival in the DG than paired females. Males demonstrated a similar, but non-significant pattern. No differences in cellular proliferation or cell survival were found in the subventricular zone (SVZ), or medial amygdala (MeA). These results add to the evidence which demonstrates that neurogenic responses to environmental conditions are not identical across species. These data may be critical in understanding the functional significance of neurogenesis as it relates to the interactions between social systems, social environment and the display of social behaviors.
Journal: Physiology & Behavior - Volume 151, 1 November 2015, Pages 570-576