کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5923769 1571176 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Emotional disorders in adult mice heterozygous for the transcription factor Phox2b
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Emotional disorders in adult mice heterozygous for the transcription factor Phox2b
چکیده انگلیسی
Phox2b is an essential transcription factor for the development of the autonomic nervous system. Mice carrying one invalidated Phox2b allele (Phox2b+/−) show mild autonomic disorders including sleep apneas, and impairments in chemosensitivity and thermoregulation that recover within 10 days of postnatal age. Because Phox2b is not expressed above the pons nor in the cerebellum, this mutation is not expected to affect brain development and cognitive functioning directly. However, the transient physiological disorders in Phox2b+/− mice might impair neurodevelopment. To examine this possibility, we conducted a behavioral test battery of emotional, motor, and cognitive functioning in adult Phox2b+/− mice and their wildtype littermates (Phox2b+/+). Adult Phox2b+/− mice showed altered exploratory behavior in the open field and in the elevated plus maze, both indicative of anxiety. Phox2b+/− mice did not show cognitive or motor impairments. These results suggest that also mild autonomic control deficits may disturb long-term emotional development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 141, 15 March 2015, Pages 120-126
نویسندگان
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