کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5923876 | 1571178 | 2015 | 7 صفحه PDF | دانلود رایگان |
- Guinea pig depressive-like response sensitized with repeated maternal separations
- Febrile response also sensitized with repeated maternal separation
- 14Â mg/kg of naproxen reduced behavioral response to early and later separations
- 28Â mg/kg of naproxen reduced febrile response to early separations
- Prostaglandins may mediate sensitization of maternal separation effects
Early life stress can increase susceptibility for later development of depressive illness though a process thought to involve inflammatory mediators. Isolated guinea pig pups exhibit a passive, depressive-like behavioral response and fever that appear mediated by proinflammatory activity, and which sensitize with repeated separations. Treatment with an anti-inflammatory can attenuate the behavioral response during the initial separation and separation the following day. Here we used the cyclooxygenase inhibitor naproxen to examine the role of prostaglandins in mediating the depressive-like behavior and core body temperature of young guinea pigs during an initial separation, separation the next day, and separation 10Â days after the first. The passive, depressive-like behavior as well as fever sensitized with repeated separation. Three days of injection with 14Â mg/kg of naproxen prior to the initial separation reduced depressive-like behavior during all three separations. A 28Â mg/kg dose of naproxen, however, had minimal effect on behavior. Fever during the early separations was moderated by naproxen, but only at the higher dose. These results suggest a role of prostaglandins in the behavioral and febrile response to maternal separation, and particularly in the sensitization of depressive-like behavior following repeated separation.
Journal: Physiology & Behavior - Volume 139, February 2015, Pages 34-40