کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5924917 1166336 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of testosterone administration and gonadectomy on incentive downshift and open field activity in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Effects of testosterone administration and gonadectomy on incentive downshift and open field activity in rats
چکیده انگلیسی

Previous research showed that the effects of incentive downshift in male rats are attenuated by a pretrial opportunity to ejaculate. Because ejaculation raises testosterone (T) levels and has anxiolytic-like effects in male rats, the present experiments were designed to assess the role of T and gonadectomy (GDX) on two situations involving incentive downshift. In consummatory successive negative contrast, a downshift from 32% to 4% sucrose leads to consummatory suppression. T alleviates such suppression (Experiment 1), but GDX does not affect it (Experiment 3). In consummatory extinction, animals are downshifted from 32% sucrose to an empty sipper tube. T enhances consummatory extinction (Experiment 2), but GDX does not affect it (Experiment 4). In agreement with published results, T increases (Experiment 2) and GDX reduces (Experiment 4) activity in the central area of an open field, thus behaviorally validating these manipulations. The results are discussed in terms of the anxiolytic-like properties of androgen hormones.

►Testosterone has anxiolytic effects in a wide variety of tasks. ►Anxiety plays a role in situations involving incentive downshifts. ►Testosterone treatment before and during incentive downshift reduced anxiety. ►Gonadectomy did not have a measurable effect on incentive downshift.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 106, Issue 5, 16 July 2012, Pages 657-663
نویسندگان
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