Cholinergic modulation of food and drug satiety and withdrawal

► Cholinergic interneurons in the dorsal striatum have a role in food and drug intake. ► Acetylcholine (ACh) activation in the nucleus accumbens (NAc) will suppress feeding. ► Antagonism of ACh receptors in the ventral tegmental area can reduce drug intake. ► Imbalance in accumbens dopamine/ACh is associated with drug and food withdrawal.