Melatonin administrated immediately before an intense exercise reverses oxidative stress, improves immunological defenses and lipid metabolism in football players

► Melatonin is a molecule with antioxidant, metabolic and immunomodulatory properties. ► Melatonin administration decreased the oxidative stress generated by exercise. ► Melatonin administration increased the serum total antioxidant activity of athletes. ► Melatonin increased consumption of cellular lipids and decreased blood levels. ► Melatonin improved the defense system of athletes by increasing the serum IgA. ► Melatonin is healthy, no doping and improves the physical condition of athletes.