Prolame ameliorates anxiety and spatial learning and memory impairment induced by ovariectomy in rats

► Prolame's effects on anxiety, spatial learning were studied in ovariectomized rats. ► Dendritic spine density and nNOS activity were assessed. ► Data indicate that prolame ameliorates the impairments caused by ovariectomy. ► Increased nNOS activity and dendritic relocation may underlie these improvements.