Rats that binge eat fat-rich food do not show somatic signs or anxiety associated with opiate-like withdrawal: Implications for nutrient-specific food addiction behaviors

► Studies show neurochemical and behavioral indices of addiction when animals overeat a sugar-rich diet. ► Naloxone-precipitated withdrawal was not seen in rats binge eating a variety of high-fat, sweet diets. ► Deprivation-induced withdrawal was not seen in rats binge eating a variety of high-fat, sweet diets. ► Body weight reduction did not affect naloxone-precipitated withdrawal in rats with a high-fat, sweet diet. ► Rats that binge eat sweet-fat combinations do not show signs of opiate-like withdrawal under the conditions used.