کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5925313 1166344 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intragastric infusion of pea-protein hydrolysate reduces test-meal size in rats more than pea protein
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Intragastric infusion of pea-protein hydrolysate reduces test-meal size in rats more than pea protein
چکیده انگلیسی

Because protein hydrolysates are digested faster than the corresponding proteins, they may increase or hasten the acute eating-inhibitory effect of protein. Potential mediating mechanisms include accelerated or greater release of satiating gut peptides and activation of metabolic signals that inhibit eating. We tested these hypotheses in adult male rats that were surgically equipped with intragastric (IG) cannulas and adapted to 30-min test meals at dark onset after 14-h food deprivation. Equiosmotic 12 ml loads of saline-urea control (C), 13.6% pea protein (PP), or 13.6% PP hydrolysate (PPH, DSM/DFS, Delft, The Netherlands) solutions were IG infused in 1 min just before test meals. PPH reduced test-meal size compared to C more than PP (− 3.8 ± 0.3 g vs. −2.6 ± 0.4 g; P < 0.0001). Plasma glutamate increased more after PPH than PP (P < 0.0001). Plasma lactate, alanine, insulin, glucagon, GLP-1 and paracetemol (an index of gastric emptying) all increased similarly, and glucose decreased similarly, after PPH or PP. Finally, PPH still reduced test-meal size more than PP (− 4.6 ± 0.3 g vs. −3.1 ± 0.4 g; P < 0.001) in rats after subdiaphragmatic vagal deafferentation, indicating that abdominal vagal afferents are not necessary for the eating-inhibitory effects of PP and PPH and, by extension, that gut peptides whose satiating effects depend on intact vagal afferents (e.g., CCK and glucagon) do not play crucial roles. Thus, PPH reduced short-term food intake more than PP under our conditions, but the mechanism(s) involved remain unclear.

► Intragastric pea-protein hydrolysate reduces intake more than intragastric pea protein. ► The effect does not require abdominal vagal afferents. ► It does not appear to be due to differences in GLP-1, glucagon, insulin or gastric emptying. ► Glutamate may somehow be involved.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 104, Issue 5, 24 October 2011, Pages 1041-1047
نویسندگان
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