Behavioral responses to glutamate receptor agonists and antagonists implicate the involvement of brain-expressed mGluR4 and mGluR1 in taste transduction for umami in mice

► Detection threshold procedure showed L-AP4 taste thresholds at 0.0009-0.0019 mM. ► CTA tests also showed higher sensitivity to L-AP4, MSG, or MPG. ► Behavioral response to mGluR agonist was suppressed by antagonist for mGluR 4 or 1. ► Our results suggest that brain-expressed mGluR 4 and 1 contribute to umami reception.