کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5925513 1166353 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Obese adolescents with eating disorders: Analysis of metabolic and inflammatory states
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Obese adolescents with eating disorders: Analysis of metabolic and inflammatory states
چکیده انگلیسی

ObjectiveThe purpose of the present investigation was to compare the effect of interdisciplinary therapy on the physical and metabolic profiles, including body composition, insulin resistance and sensitivity as well as adiponectin and leptin concentrations, of obese adolescents with and without eating disorder symptoms.MethodsA total of 83 obese adolescents (28 with and 55 without eating disorder symptoms) were enrolled for 1 year of interdisciplinary weight-loss therapy (clinical, nutritional, exercise, physiotherapy and psychological). Bulimic and binge eating symptoms were measured by the Bulimic Investigatory Test, Edinburgh, and the Binge Eating Scale, respectively. Leptin and adiponectin concentrations were measured with enzyme-linked immunosorbent assay kits. Visceral and subcutaneous fat were assessed by ultrasonography.ResultsBoth groups demonstrated improved body mass, body mass index, body fat (%), lean mass, visceral fat, subcutaneous fat, homeostasis model assessment insulin-resistance index (HOMA-IR), quantitative insulin sensitivity check index, total cholesterol, LDL-cholesterol, VLDL, triglycerides, adiponectin and leptin concentrations after therapy. We found a positive correlation between leptin concentrations and subcutaneous fat in the control group and a negative correlation between adiponectin concentrations and HOMA-IR and fat mass (%). The prevalence of obese adolescents with eating disorders was reduced by 89% after 1 year of interdisciplinary therapy.ConclusionThe eating disorder symptoms did not impair the metabolic state during weight loss therapy of obese adolescents. Additionally, long-term interdisciplinary therapy was effective in reducing the chances of developing several co-morbidities in both groups.

► We evaluated the effect of weight loss therapy of obese with eating disorders. ► We verified an improvement of metabolic profile of all volunteers after therapy. ► The improvement of inflammatory state was observed in both groups. ► Eating disorders did not influence in the benefits of weight loss therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 105, Issue 2, 18 January 2012, Pages 175-180
نویسندگان
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