کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5925763 1166364 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Body fat distribution and organ weights of 14 common strains and a 22-strain consomic panel of rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Body fat distribution and organ weights of 14 common strains and a 22-strain consomic panel of rats
چکیده انگلیسی

The goal of this study was to determine the adiposity of a range of rat strains, including a panel of consomics, to estimate heritability. To that end, we assessed the body fat distribution and organ weights of groups of adult male rats from 3 outbred strains, 11 inbred strains and 22 consomic strains. We measured the weights of the gonadal, retroperitoneal, mesenteric, femoral, subscapular and pericardial white fat depots, the subscapular brown fat depot, the kidneys, liver, heart, spleen, and brain. Strains were compared for the measured weight of each of these adipose depots and organs, and also for these weights adjusted statistically for body size. All individual adipose depot and organ weights were highly heritable, in most cases h2 > 0.50. The fourteen inbred and outbred rat strains were not very different in body length but there was a three-fold difference in body weight, and up to a twenty-fold difference in the weight of some adipose depots. Comparison of the FHH-Chr nBN consomic strains with the FHH host strain revealed 98 quantitative trait loci (QTLs) for body composition and organ weight, with the introgressed chromosome reducing weight or adiposity in most cases. These results can be used to guide the choice of appropriate rat strains for future studies of the genetic architecture of obesity and body size.

Research highlights► Common strains of rats differ over twenty-fold in the weight of some adipose depots. ► Body fat distribution is highly heritable in rats. ► Consomic rat strains differ in body composition and were used to identify 98 QTLs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 103, Issue 5, 6 July 2011, Pages 523-529
نویسندگان
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