کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5925802 1166366 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adiposity signaling and meal size control
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Adiposity signaling and meal size control
چکیده انگلیسی

Signaling from energy stores provides feedback on overall nutrient availability to influence food intake. Beginning with seminal studies by Woods and colleagues identifying insulin as an adiposity signal, it has become clear that such factors affect food intake by modulating the efficacy of within meal feedback satiety signals. More recent work with leptin has revealed actions of the hormone in modulating the efficacy of multiple gut feedback signals, identified the dorsal hindbrain as a site of signal integration and suggested both local and descending hypothalamic to hindbrain actions in mediating these effects. The original work by Woods and colleagues provided the necessary experimental paradigms for these advances.

Research Highlights► Signaling from energy stores provide feedback to affect the satiety. ► Leptin interacts with within-meal satiety signaling to inhibit food intake. ► Leptin's actions to affect meals are distributed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 103, Issue 1, 18 April 2011, Pages 21-24
نویسندگان
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