کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5926596 | 1167381 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The increased ventilatory response to exercise in pregnancy reflects alterations in the respiratory control systems ventilatory recruitment threshold for CO2
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We tested the hypothesis that the magnitude of the pregnancy-induced increase in exercise hyperpnea is predictable based on the level at which PaCO2 is regulated at rest. We performed a detailed retrospective analysis of previous data from 25 healthy young women who performed exercise and rebreathing tests in the third trimester (TM3; 36.5 ± 0.2 weeks gestation; mean ± SEM) and again 20.4 ± 1.7 weeks post-partum (PP). At rest, arterialized venous blood was obtained for the estimation of PaCO2, [H+] and [HCO3â]; and serum progesterone ([P4]) and 17β-estradiol ([E2]) concentrations. Duffin's modified hyperoxic rebreathing procedure was used to evaluate changes in central ventilatory chemoreflex control characteristics at rest. Breath-by-breath ventilatory and gas exchange variables were measured at rest and during symptom-limited incremental cycle exercise tests. At rest in TM3 compared with PP: PaCO2, [H+], [HCO3â] and the central chemoreflex ventilatory recruitment threshold for PCO2 (VRTCO2) decreased, while ventilation (VËE), [P4], [E2] and central chemoreflex sensitivity (VËES) increased (all p â¤Â 0.001). The slope of the linear relation between VËE and VËCO2 during exercise was significantly higher in TM3 vs. PP (31.2 ± 0.6 vs. 27.5 ± 0.5, p < 0.001). The magnitude of this change in the VËE-VËCO2 slope correlated significantly with concurrent reductions in each of the VRTCO2 (R2 = 0.619, p < 0.001), PaCO2 (R2 = 0.203, p = 0.024) and [HCO3â] (R2 = 0.189, p = 0.030); and was independent (p > 0.05) of changes in [P4], [E2] and VËES. In conclusion, the increased ventilatory response to exercise in pregnancy can be explained, in large part, by reductions in the respiratory control system's resting PCO2 equilibrium point as manifest primarily by reductions in the VRTCO2.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 171, Issue 2, 30 April 2010, Pages 75-82
Journal: Respiratory Physiology & Neurobiology - Volume 171, Issue 2, 30 April 2010, Pages 75-82
نویسندگان
Dennis Jensen, Katherine A. Webb, Denis E. O'donnell,