کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
59320 1419466 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cobalt Nanoparticles Promoted Highly Efficient One Pot Four-Component Synthesis of 1,4-Dihydropyridines under Solvent-Free Conditions
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Cobalt Nanoparticles Promoted Highly Efficient One Pot Four-Component Synthesis of 1,4-Dihydropyridines under Solvent-Free Conditions
چکیده انگلیسی

A straightforward and general method has been developed for the synthesis of C5-unsubstitiuted 1,4-dihydropyridines by a reaction using dimedone, acetophenone, aromatic aldehydes, and ammonium acetate in the presence of a catalytic amount of Co nanoparticles as a heterogeneous and eco-friendly catalyst with high catalytic activity at room temperature under solvent-free conditions. This catalyst is easily separated by magnetic devices and can be reused without any apparent loss of activity for the reaction. In addition, it is very interesting that when using Co nanoparticles as a catalyst, spatially-hindered aldehydes such as 2-methoxy-, 2-fluoro-, and 2-chloro-aldehydes are suitable for this reaction.

This paper presents a simple and convenient route for the preparation of 1,4-dihydropyridines over cobalt nanoparticles by a four-component reaction under solvent-free conditions. The reaction under the influence of heterogeneous catalysts such as Co nanoparticles has enhanced efficiency from an economic as well as a green chemistry point of view.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Journal of Catalysis - Volume 32, Issues 11–12, November–December 2011, Pages 1850–1855
نویسندگان
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