Pd-catalyzed intramolecular aminofluorination of allylic sulfamides

A facile Pd-catalyzed intramolecular aminofluorination reaction of allylic sulfamides was developed that can be used to prepare fluorinated 1,3-diamine derivatives. Acetic acid was essential for regulation to give the major 6-endo cyclization products.

Graphical AbstractA facile Pd-catalyzed intramolecular aminofluorination reaction of unactivated alkenes was developed that can be used to prepare fluorinated 1,3-diamine derivatives.Figure optionsDownload as PowerPoint slide