کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
59519 | 1419463 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Ammonium Dihydrogen Phosphate Catalyst for One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Ammonium Dihydrogen Phosphate Catalyst for One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones](/preview/png/59519.png)
A one-pot three component Biginelli condensation of different substituted aromatic and aliphatic aldehydes with ethyl acetoacetate and urea to the respective 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions that is simple, effective, and environmentally friendly was shown. Ammonium dihydrogen phosphate (NH4H2PO4) was used as a non-toxic, inexpensive, and easily available catalyst. The facile reaction condition and simple isolation and purification procedures of this method make it a good option for the synthesis of dihydropyrimidinones.
A simple and environmentally benign protocol for the preparation of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions using easily available ammonium dihydrogen phosphate (NH4H2PO4) as catalyst is shown.Figure optionsDownload as PowerPoint slide
Journal: Chinese Journal of Catalysis - Volume 33, Issues 4–6, April–June 2012, Pages 659–665