کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5963000 1576127 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of late exercise on cardiac remodeling and myocardial calcium handling proteins in rats with moderate and large size myocardial infarction
ترجمه فارسی عنوان
اثرات تمرین دیر بر روی بازسازی قلب و پروتئین های نگهداری کلسیم قلب در موش های صحرایی با انفارکتوس میوکارد متوسط ​​و بزرگ
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundPhysical exercise attenuates myocardial infarction (MI)-induced cardiac remodeling. However, it is unsettled whether late exercise modulates post-infarction cardiac remodeling differentially according to infarct size. We investigated the effects of exercise started at late stage heart failure on cardiac remodeling in rats with moderate and large sized MI.MethodsThree months after MI, rats were assigned into sedentary and exercise groups. Exercise rats underwent treadmill for three months. After assessing infarct size by histological analysis, rats were subdivided into four groups: moderate MI sedentary (Mod MI-Sed; n = 7), Mod MI exercised (Mod MI-Ex; n = 7), Large MI-Sed (n = 11), and Large MI-Ex (n = 10).ResultsBefore exercise, MI-induced cardiac changes were demonstrated by comparing results to a Sham group; alterations were more intense in rats with large than moderate MI size. Systolic function, evaluated by echocardiogram using the variation in LV fractional area change between after and before exercise, was improved in exercise than sedentary groups. Calsequestrin expression increased in exercised compared to sedentary groups. L-type calcium channel was higher in Mod MI-Ex than Mod MI-Sed. SERCA2a, phospholamban, and Na+/Ca2 + exchanger expression did not differ between groups.ConclusionLate exercise improves systolic function and modulates intracellular calcium signaling proteins in rats with moderate and large MI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 221, 15 October 2016, Pages 406-412
نویسندگان
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