Concomitant measurements of serum annexin A5 levels and hematological indices as markers in recent and old myocardial infarction with low ejection fraction: A preliminary study

- Hematological indices are markers of acute cardiac injury.
- Ejection fraction of acute and chronic MI is significantly less than the healthy subjects.
- Serum annexin is diagnostic marker of acute or chronic MI with low ejection fraction.
- AnxA5 of acute and chronic MI patients are significantly higher than healthy subjects.

BackgroundSerum annexin A5 (anxA5) level is significantly increased in patients with acute coronary syndrome. Hematological indices are significantly increased in patients with ischemic heart disease. This study aimed to demonstrate the changes in the distribution of blood cells and the levels of anxA5 in patients presented with significant low ejection fraction ST-elevation acute myocardial infarction (STEMI) in comparison with corresponding patients with ischemic heart disease.MethodsPatients with low ejection fraction presenting at Hospital of Diyala University of Iraq were enrolled. Electrocardiograph (ECG), echocardiograph, hematological indices, serum annexin V (anxV) levels and the determinants of the cardio-metabolic risk factors were performed. Based on clinical examination, ECG findings and laboratory tests, patients were divided into healthy subjects (n = 20); patients with acute MI (n = 40) and with chronic MI (n = 12).ResultsAcute MI has significant high levels of serum triglyceride, uric acid and high mean value of red cell distribution width (RDW) compared with healthy subjects and chronic MI. Platelet distribution width (PDW) is significantly reduced in patients of acute MI and chronic MI compared with healthy subjects, whereas the plateletcrit (PCT) is significantly higher in acute MI compared with healthy subjects. There is an insignificant difference between the means of serum anxA5 levels of acute MI (35.6 ± 7.2 ng/ml) and chronic MI (32.4 ± 8.9 ng/ml), but significantly higher than the cutoff level of the healthy subjects (5 ng/ml).ConclusionsMeasurement of serum annexin level is a useful diagnostic marker of acute or chronic MI with low ejection fraction.