کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5963903 1576134 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Perioperative hyperoxia - Long-term impact on cardiovascular complications after abdominal surgery, a post hoc analysis of the PROXI trial
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Perioperative hyperoxia - Long-term impact on cardiovascular complications after abdominal surgery, a post hoc analysis of the PROXI trial
چکیده انگلیسی

BackgroundIncreased long-term mortality was found in patients exposed to perioperative hyperoxia in the PROXI trial, where patients undergoing laparotomy were randomised to 80% versus 30% oxygen during and after surgery. This post hoc follow-up study assessed the impact of perioperative hyperoxia on long-term risk of cardiovascular events.MethodsA total of 1386 patients undergoing either elective or emergency laparotomy were randomised to 80% versus 30% oxygen during and two hours after surgery. At follow-up, the primary outcome of acute coronary syndrome was assessed. Secondary outcomes included myocardial infarction, other heart disease, and acute coronary syndrome or death. Data were analysed in the Cox proportional hazards model.ResultsThe primary outcome, acute coronary syndrome, occurred in 2.5% versus 1.3% in the 80% versus 30% oxygen group; HR 2.15 (95% CI 0.96-4.84). Patients in the 80% oxygen group had significantly increased risk of myocardial infarction; HR 2.86 (95% CI 1.10-7.44), other heart disease; HR 1.40 (95% 1.06-1.83), and acute coronary syndrome or death; HR 1.22 (95% CI 1.01-1.49).ConclusionsPerioperative hyperoxia may be associated with an increased long-term risk of myocardial infarction and other heart disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 215, 15 July 2016, Pages 238-243
نویسندگان
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