کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5963940 1576134 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Obesity can predict and promote systemic inflammation in healthy adults
ترجمه فارسی عنوان
چاقی می تواند التهاب سیستمیک را در بزرگسالان سالم پیش بینی کند
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundTo find out the differences on biomedical data between obese and non-obese participants, and to identify risk factors associated with systemic inflammation in healthy Palestinian adults.MethodologyA cross-sectional study involved 105 apparently healthy adults. Interview questionnaire was used to collect personal information. Participants were excluded if they suffered from acute or chronic inflammatory diseases, or continued using medicines, which might affect the biomedical results.ResultsIn association with increased Body Mass Index (BMI), the obese group displayed significant higher markers including: interleukin 6 (IL-6), high sensitivity C reactive protein (hs-CRP), total cholesterol (TC), systolic blood pressure (SBP), and diastolic blood pressure (DBP). Obese group in association with increased waist circumference (WC) was higher significantly in inflammatory markers (IL-6, hs-CRP), lipid profile (TC) and triglyceride (TG), and blood pressure (SBP, DBP). A tertile of a feature of systemic inflammation (hs-CRP) was created, by Ordinal Logistic Regression, after adjusting for the age, gender, smoking habits, physical activity pattern, father and mother's health history; risk factors were the increased BMI [OR: 1.24] (95% CI: 1.005-1.548, P = 0.050), IL-6 [OR: 3.35] (95% CI: 1.341-8.398, P = 0.010), DBP [OR: 1.19] (95% CI: 1.034-1.367, P = 0.015), and reduced Adiponectin [OR: 0.59] (95% CI: 0.435-0.820, P = 0.001). Finally, BMI correlated with IL-6 and hs-CRP (r = 0.326, P = 0.005; r = 0.347, P < 0.001; respectively), and hs-CRP correlated with IL-6 (r = 0.303, P = 0.010), and inversely with Adiponectin (r = − 0.342, P = 0.001).ConclusionThe increased level of IL-6 and reduced Adiponectin, which strongly associated with obesity, indicated that having high BMI is a useful marker in association with IL-6 and further developed systemic inflammation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 215, 15 July 2016, Pages 318-324
نویسندگان
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