کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5965867 | 1576153 | 2015 | 4 صفحه PDF | دانلود رایگان |

- β-Adrenoceptor polymorphisms are similar in the two groups.
- Different cardiovascular risk factor profile among TTC and STEMI patients
- On top of sympathetic pathway, they are fundamental contributors in STEMI.
AimCatecholamine excess along with an exaggerated sympathetic stimulation appears to play a major role in the pathophysiological mechanism of tako-tsubo cardiomyopathy (TTC), which mimics acute ST-elevation myocardial infarction (STEMI). The aim of the present study was to investigate differences in the distribution of allelic variants of β1- and β2-adrenoceptors between TTC and anterior STEMI patients compared to normal subjects.Methods and resultsβ1- and/or β2-adrenoceptor polymorphisms in 97 patients with TTC (92 females, 96%; mean age 66.8 ± 11.6 years; range 35 to 87 years) were compared with 81 patients with anterior STEMI (77 females, 95%; mean age 72.5 ± 12.8 years; range 32 to 96 years) and 101 controls (95 females, 94%; mean age 62.3 ± 10.4 years; range 44 to 92 years). Differences in genotype frequencies were assessed using the Pearson Ï2 test. β1-Adrenoceptor (Gly389Arg) and β2-adrenoceptor (Arg16Gly and Gln27Glu) genotype frequencies were significantly different among groups (p < 0.001, p = 0.024, p = 0.008, respectively). However, differences did not achieve statistical significance when TTC and anterior STEMI patients were compared by post-hoc analysis. The cardiovascular risk factor profile was worse in anterior STEMI patients, who more often had a history of systemic arterial hypertension, diabetes and coronary artery disease.ConclusionsIn a large TTC cohort compared with anterior STEMI patients, β-adrenoceptor polymorphisms were similar. However, the cardiovascular risk factor profile was different between the two groups. β-Adrenoceptor polymorphisms in TTC patients differed from normal subjects.
Journal: International Journal of Cardiology - Volume 199, 15 November 2015, Pages 189-192