کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5966522 1576158 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Low testosterone in men predicts impaired arterial elasticity and microvascular function
ترجمه فارسی عنوان
تستوسترون پایین در مردان، تخریب کشش شریانی و عملکرد میکرو قوس را پیش بینی می کند
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundA low testosterone level in men is associated with increased adiposity, insulin resistance, and dyslipidemia. Whether low testosterone level is associated with arterial stiffness and endothelial and microvascular dysfunction remains unknown and was investigated in this study.MethodsSerum testosterone was measured in 237 healthy men aged 50 years (SD 12). Endothelial and microvascular function were assessed as brachial artery flow-mediated dilation (FMD) and digital reactive hyperemia index (RHI), respectively. Arterial stiffness was evaluated by tonometry-derived pulse wave velocity (PWV) and central augmentation index (AIX).ResultsMean total testosterone level was 16.3 nmol/L (SD 6.11) and 25% of subjects had low levels (< 12.0 nmol/L). Testosterone level correlated positively with RHI (r = 0.24, p < 0.001) and inversely with AIX (r = − 0.14, p = 0.033) but not with FMD or PWV, indicating impaired microvascular hyperemia and arterial elasticity with lower testosterone levels. After multivariate adjustment for the Framingham Risk Score and weight, testosterone level remained an independent predictor of RHI and AIX (β = 0.23, − 0.13; p = 0.001, 0.04, respectively).ConclusionIn men with few co-morbidities, lower serum testosterone level is associated with microvascular dysfunction and increased pulse wave reflections, mechanisms by which lower testosterone levels may confer increased cardiovascular risk. Whether normalization of low testosterone level improves vascular function needs further investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 194, 1 September 2015, Pages 94-99
نویسندگان
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