کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5967097 1576163 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Disease complexity in acute coronary syndrome is related to the patient's immunological status
ترجمه فارسی عنوان
پیچیدگی بیماری در سندرم حاد کرونر مربوط به وضعیت ایمنی شناسی بیمار است
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundOur aim was to investigate whether patients with acute coronary syndrome (ACS) display an overall T cell immunosenescence that could be contributing to worsening the stage of the disease.Methods and resultsWe compared the immunological status of 52 ACS patients, 21 controls with absence of coronary artery disease (CAD) (C1), and 50 healthy individuals (C2). We characterized leukocyte and T lymphocyte subpopulations by flow cytometry. CAD was classified according to SYNTAX score, number of diseased coronary vessels, previous episodes of ACS and left ventricular ejection fraction (LVEF). ACS patients showed an increased number of total leukocytes, neutrophils and monocytes (p < 0.001), but a decreased number of lymphocytes (p < 0.05). ACS patients had significantly higher levels of NK cells and CD8 + T-cells (p < 0.05). ACS was associated with high differentiation in CD4 + and CD8 + T-lymphocytes. Frequencies of naïve, naïve CD31 +, EM1, and pE1 subsets were significantly reduced in ACS patients (p < 0.05), while EM3, EM4 (in CD4 +), and E (in CD8 +) subsets were increased (p < 0.05). Aging of T-lymphocyte subpopulations was associated with a worse SYNTAX score (p < 0.05), and aging of CD4 + T-lymphocytes with a larger number of affected vessels, larger number of previous ACS episodes and lower LVEF, in ACS patients (p > 0.05). Furthermore, the proliferation ability of CD4 + and CD8 + T-lymphocytes was significantly impaired in ACS patients (p < 0.05), although they had increased activation (p < 0.05).ConclusionsWe conclude that ACS patients show a higher degree of T-lymphocyte immunosenescence than healthy controls, which could contribute to disease impairment through a compromised adaptive immune response.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 189, 15 June 2015, Pages 115-123
نویسندگان
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