کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5969517 | 1576175 | 2014 | 4 صفحه PDF | دانلود رایگان |
Background/objectivesThere are few studies investigating the long-term association between childhood blood pressure (BP) and adult cardiovascular remodeling. We seek to examine the effect of elevated childhood BP on cardiovascular remodeling in early or middle adulthood.MethodsWe used the “Beijing BP Cohort Study”, where 1259 subjects aged 6-18Â years old were followed over 24Â years from childhood (1987) to early or middle adulthood (2011). Anthropometric measures and BP were obtained at baseline and follow-up examinations. Carotid-femoral pulse wave velocity (cfPWV), carotid intima-media thickness (cIMT), and left ventricular mass index (LVMI) were measured to assess cardiovascular remodeling in early or middle adulthood. Multiple logistic regression models were used to assess the odds ratio (OR) and 95% confidence interval (CI) for cardiovascular remodeling.Results82 out of 384 children with elevated BP (21.4%) had adult hypertension. Compared to those with normal BP, children with elevated BP were at 2.1 times (95% CI: 1.4-3.1) likely to develop hypertension in early or middle adulthood. Compared to those with normal BP, children with elevated BP were at higher OR of developing high cfPWV (ORÂ =Â 1.8, 95% CIÂ =Â 1.3-2.4), high cIMT (1.4, 1.0-1.9), or high LVMI (1.4, 1.0-1.9) in early or middle adulthood. The ORs for remodeling (for any measures) were 1.4 (0.9-2.0) in early adulthood for children age 6-11Â years, and 1.6 (1.1-2.4) in middle adulthood for those aged 12-18Â years.ConclusionsChildren with elevated BP from 6Â years old have accelerated remodeling on both cardiac and arterial system in early or middle adulthood.
Journal: International Journal of Cardiology - Volume 177, Issue 3, 20 December 2014, Pages 836-839