کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5970201 1576185 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Repetitive use of levosimendan for treatment of chronic advanced heart failure: Clinical evidence, practical considerations, and perspectives: An expert panel consensus
ترجمه فارسی عنوان
استفاده تکراری از لوزو ماندان برای درمان نارسایی مزمن قلبی: شواهد بالینی، ملاحظات عملی و دیدگاه ها: یک پیمان کارشناس پیمان
کلمات کلیدی
لووسیمندان، نارسایی مزمن قلبی، درمان ناباروری تکراری،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundThe intravenous inodilator levosimendan was developed for the treatment of patients with acutely decompensated heart failure. In the last decade scientific and clinical interest has arisen for its repetitive or intermittent use in patients with advanced chronic, but not necessarily acutely decompensated, heart failure. Recent studies have suggested long-lasting favourable effects of levosimendan when administered repetitively, in terms of haemodynamic parameters, neurohormonal and inflammatory markers, and clinical outcomes. The existing data, however, requires further exploration to allow for definitive conclusions on the safety and clinical efficacy of repetitive use of levosimendan.Methods and resultsA panel of 30 experts from 15 countries convened to review and discuss the existing data, and agreed on the patient groups that can be considered to potentially benefit from intermittent treatment with levosimendan. The panel gave recommendations regarding patient dosing and monitoring, derived from the available evidence and from clinical experience.ConclusionsThe current data suggest that in selected patients and support out-of-hospital care, intermittent/repetitive levosimendan can be used in advanced heart failure to maintain patient stability. Further studies are needed to focus on morbidity and mortality outcomes, dosing intervals, and patient monitoring. Recommendations for the design of further clinical studies are made.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 174, Issue 2, 15 June 2014, Pages 360-367
نویسندگان
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