کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5973030 1576196 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Progression in attenuating myocardial reperfusion injury: An overview
ترجمه فارسی عنوان
پیشرفت در آسیب مجدد آسیب به ریفرینگ قلب: کاهش چشمگیر
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

Reperfusion by means of percutaneous coronary intervention or thrombolytic therapy is the most effective treatment for acute myocardial infarction, markedly reducing mortality and morbidity. Reperfusion however induces necrotic and apoptotic damages to cardiomyocytes, that were viable prior to reperfusion, a process called lethal reperfusion injury. This process, consisting of many single processes, may be responsible of up to half of the final infarct size. A myriad of therapies as an adjunct to reperfusion have been studied with the purpose to attenuate reperfusion injury. The majority of these studies have been disappointing or contradicting, but recent proof-of-concept trials show that reperfusion injury still is a legitimate target. This overview will discuss these trials, the progression in attenuating myocardial reperfusion injury, promising therapies, and future perspectives.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 170, Issue 3, 1 January 2014, Pages 261-269
نویسندگان
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