کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5973661 1576208 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hereditary patterns of bicuspid aortic valve in a hundred families
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Hereditary patterns of bicuspid aortic valve in a hundred families
چکیده انگلیسی

BackgroundTo study the following characteristics of bicuspid aortic valves (BAVs): 1) the recurrence rate in our population, 2) patterns of hereditary transmission in different BAV morphologies and 3) the aortic dimensions of BAVs in first-degree relatives (FDRs).MethodsA cross-sectional, prospective study of 100 consecutive families of BAV patients attending a university hospital. The following aortic valve morphologies were analysed and categorised: fusion of the right and left coronary cusps (BAV type A), right and noncoronary cusps (type B) and of the left and noncoronary cusps (type C).ResultsThere were 553 subjects studied, 100 cases with a BAV (46.8 ± 15 years, 66% male, type 67% A, 32% B and 1% C; 42% with aortic dilatation), 348 FDRs (44.8% male), and 105 healthy control subjects (50% male). We detected 16 BAVs among 348 FDRs. The recurrence rates were 15% for families, 4.6% for FDRs, 7.05% in men and 2.60% in women. The morphologic concordance in family members was 68.8%. The aortic dimensions in 270 adult FDRs with a tricuspid aortic valve were significantly smaller compared with BAV patients (sinus index diameter 1.60 ± 0.19 cm/m2 vs. 1.82 ± 0.29 cm/m2, p < 0.001; tubular index diameter 1.51 ± 0.23 cm/m2 vs. 2.00 ± 0.45 cm/m2, p < 0.001) and similar to 103 control subjects(sinus index diameter 1.60 ± 0.19 cm/m2 vs. 1.59 ± 0.17 cm/m2, p = 0.600 and tubular index diameter 1.51 ± 0.23 cm/m2 vs. 1.53 ± 0.18 cm/m2, p = 0.519).ConclusionsIn our population, the BAV recurrence rate in FDRs was low (4.6%). The hereditary transmission of morphologic BAV types seems by chance, and the aortic dimensions in tricuspid FDRs are normal.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 168, Issue 4, 9 October 2013, Pages 3443-3449
نویسندگان
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