کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5975952 1576221 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Low pulmonary vascular compliance predisposes post-Fontan patients to protein-losing enteropathy
ترجمه فارسی عنوان
پایین انطباق عروق ریوی مستعد بیماران پس از فونتان به روده پروتئین از دست دادن
کلمات کلیدی
روش فونت، انتروپاتی از دست رفته پروتئین، رعایت عروق ریوی،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundProtein-losing enteropathy (PLE) is a life-threatening and poorly understood complication after the Fontan operation. We sought to determine the pre-operative risk factors for PLE which developed after the extracardiac conduit Fontan operation.MethodsTwo hundred thirty-five patients who underwent the extracardiac conduit Fontan operation as an initial Fontan type procedure (median age at operation: 3.5 years) were enrolled in this cross-sectional retrospective study. Pre-operative and peri-operative variables were surveyed through a review of medical records.ResultsWithin the median follow-up duration of 5 years, 12 patients developed PLE (12/234, 5.1%) at a median interval of 2.2 years after the Fontan procedure, and 4 died of PLE at a median interval of 1.2 years (range 0.21-7.62) after diagnosis. Factors found to be related to the time to the development of PLE on univariate analysis were pulmonary vascular compliance (Cpv) (p = 0.0019), central venous pressure at postoperative 12 hours (p = 0.0026), days of ICU stay (P = 0.0449), days of hospitalization (p = 0.0135), and days of chest tube indwelling (p = 0.0493). Multivariate analysis, however, showed that only Cpv (p = 0.0367) remained significant. The range of Cpv was 8.8-26.1 mm2/m2/mmHg (median 17.9) in patients with PLE, and 6.6-122.3 mm2/m2/mmHg (median 26.8) in patients without PLE.ConclusionsLow pulmonary vascular compliance is associated with the development of PLE after the extracardiac conduit Fontan operation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 165, Issue 3, 25 May 2013, Pages 454-457
نویسندگان
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