کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5975967 | 1576221 | 2013 | 6 صفحه PDF | دانلود رایگان |
BackgroundPathologically, the lesions responsible for acute coronary syndrome (ACS) are ruptures of vulnerable plaques (and occasionally fibrous-cap erosions or calcified nodules) with a superimposed thrombosis. We aimed to clarify the clinical presentations related to the morphologies of coronary lesions of ACS using intravascular ultrasound (IVUS) and optical coherence tomography (OCT).Methods and resultsSeventy-five culprit lesions of ACS patients were clearly assessed with IVUS and OCT. Patients were classified into two groups based on the presence or absence of a rupture of a culprit plaque as identified by OCT. Clinical characteristics and lesion morphologies were compared between the two groups. Waist circumference was significantly greater (p < 0.02) and prevalence of the metabolic syndrome (MS) higher (p = 0.0011) in the rupture group. The prevalence of prodromal angina was higher in patients without plaque ruptures (p < 0.0001). Using multivariate analysis, the MS and prodromal angina were independent predictors of rupture of a culprit coronary plaque (odds ratio (OR): 27.30, p < 0.003 and OR: 0.04, p = 0.0004, respectively). Among the components of the MS, the prevalence of abdominal obesity was a significant independent predictor of rupture of a culprit plaque (OR: 4.24, p < 0.02).ConclusionsThere are two presentations related to the coronary lesion morphologies of ACS: we should understand these aspects of ACS.
Journal: International Journal of Cardiology - Volume 165, Issue 3, 25 May 2013, Pages 506-511