کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5976190 1576209 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Associations of serum uric acid levels with arterial wave reflections and central systolic blood pressure
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Associations of serum uric acid levels with arterial wave reflections and central systolic blood pressure
چکیده انگلیسی

BackgroundUric acid may be involved in the pathogenesis of hypertension. We investigated the roles of four major hemodynamic parameters of blood pressure, including arterial stiffness, wave reflections, cardiac output (CO), and total peripheral resistance (TPR), in the association between uric acid and central systolic blood pressure (SBP-c).MethodsA sample of 1303 normotensive and untreated hypertensive Taiwanese participants (595 women, aged 30-79 years) was drawn from a community-based survey. Study subjects' baseline characteristics, biochemical parameters, carotid-femoral pulse wave velocity (cf-PWV), amplitude of the backward pressure wave decomposed from a calibrated tonometry-derived carotid pressure waveform (Pb), CO, TPR, and SBP-c were analyzed.ResultsIn multi-variate analyses adjusted for age, waist circumference, body mass index, creatinine, total cholesterol, smoking, and heart rate, uric acid significantly correlated with Pb and cf-PWV in men, and Pb and TPR in women. The correlation between uric acid and Pb remained significant in men and women when cf-PWV was further adjusted. In the final multi-variate prediction model (model r2 = 0.839) for SBP-c, the significant independent variables included uric acid (partial r2 = 0.005), Pb (partial r2 = 0.651), cf-PWV (partial r2 = 0.005), CO (partial r2 = 0.062), TPR (partial r2 = 0.021), with adjustment for age, sex, waist circumference, body mass index, creatinine, total cholesterol, smoking, and heart rate.ConclusionsUric acid was significantly independently associated with wave reflections, which is the dominant determinant of SBP-c. Uric acid was also significantly associated with SBP-c independently of the major hemodynamic parameters.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 168, Issue 3, 3 October 2013, Pages 2057-2063
نویسندگان
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