کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5976281 1576209 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of psoriasis as independent predictor of cardiovascular disease: A meta-regression analysis
ترجمه فارسی عنوان
نقش پسوریازیس به عنوان پیش بینی مستقل بیماری های قلبی عروقی: یک تجزیه و تحلیل رگرسیون
کلمات کلیدی
پسوریازیس، بیماری های قلبی عروقی، انفارکتوس،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundDespite the proved association between psoriasis and cardiovascular risk exposure, there are no data about the role of psoriasis as an independent predictor of such risk. The aim of this study was to investigate whether any association between psoriasis and excess cardiovascular risk exposure is independent from confounding factors.MethodsMeta-analysis and meta-regression analysis were performed using data extracted from observational studies (identified by MEDLINE, EMBASE and CINAHL) investigating the relationship between psoriasis and cardiovascular disease with at least 6 points on the New Castle-Ottawa quality scale. Two reviewers with methodological expertise conducted data extraction independently.ResultsThirteen studies including patients with psoriasis showed an increased risk of cardiovascular disease (RR = 1.24 [1.18-1.31]; P = 0.0001). These patients still presented a significantly larger cardiovascular risk in the presence of smoking (RR = 1.14 [CI = 1.13-1.15] P < 0.0001), obesity (RR = 1.11 [CI = 1.07-1.14] P = 0.0003) and hyperlipidemia (RR = 1.05 [CI = 1.03-1.07] P = 0.0006), but not in the presence of hypertension (RR = 1.03 [CI = 0.98-1.09] P = 0.4647) and diabetes (RR = 0.95 [CI = 0.90-1.01] P = 0.6502).ConclusionsPatients with psoriasis carry an about 25% increased relative risk of cardiovascular disease. This risk appears to be independent of smoking, obesity and hyperlipidemia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 168, Issue 3, 3 October 2013, Pages 2282-2288
نویسندگان
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