کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5977017 | 1576223 | 2013 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Three-year follow-up of the MULTIcentre evaluation of Single high-dose Bolus TiRofiban versus Abciximab with Sirolimus-eluting STEnt or Bare-Metal Stent in Acute Myocardial Infarction StudY (MULTISTRATEGY) Three-year follow-up of the MULTIcentre evaluation of Single high-dose Bolus TiRofiban versus Abciximab with Sirolimus-eluting STEnt or Bare-Metal Stent in Acute Myocardial Infarction StudY (MULTISTRATEGY)](/preview/png/5977017.png)
BackgroundThe Multicentre Evaluation of Single high-dose Bolus TiRofiban versus Abciximab with Sirolimus-eluting Stent or Bare Metal Stent in Acute Myocardial Infarction Study [MULTISTRATEGY]) randomised 745 patients with ST-elevation myocardial infarction to receive high-dose bolus (HDB) tirofiban or abciximab infusion and sirolimus-eluting (SES) or uncoated-stent (BMS) implantation. Tirofiban was non-inferior to abciximab in terms of ST-segment resolution after intervention, whereas 8 month-major adverse cardiac events occurred in 14.5% in the BMS and 7.8% in the SES groups (PÂ =Â 0.0039), reflecting a reduction of reintervention rates (10.2% vs. 3.2%). A three-year follow-up was performed to extend previous short- to mid-term findings.Methods and resultsComplete data at 3Â years was available for 736 patients (99%). All-cause mortality was 6.7% in the tirofiban and 7.8% in the abciximab (PÂ =Â 0.56) and 7.5% in the BMS vs 7.0 in the SES groups, PÂ =Â 0.79. The composite of all-cause death or MI was identical at 12.9% in tirofiban and abciximab groups, PÂ =Â 0.99 and it occurred in 13.2% in the BMS vs. 12.6% in the SES groups (PÂ =Â 0.83). The need for reintervention remained more than twice as common with BMS (13.7%; versus 6.2%, PÂ =Â 0.0006). The cumulative rate of stent thrombosis (ST) did not differ. This is inspite of a higher very late definite, probable or possible ST thrombosis rate in the SES group.ConclusionsThe 3-year follow-up of MULTISTRATEGY demonstrated comparable outcomes with HDB Tirofiban or abciximab and a sustained efficacy of SES to reduce reintervention with no difference in death, repeat MI or ST.
Journal: International Journal of Cardiology - Volume 165, Issue 1, 30 April 2013, Pages 134-141