کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5978177 1576247 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Left atrial remodeling and reduced atrial pump function after chronic right ventricular apical pacing in patients with preserved ejection fraction
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Left atrial remodeling and reduced atrial pump function after chronic right ventricular apical pacing in patients with preserved ejection fraction
چکیده انگلیسی

BackgroundThis prospective study was to examine the impact of right ventricular apical (RVA) pacing on atrial remodeling and function.Methods and results103 patients (age 70 ± 11 years; 53 men) with preserved left ventricular (LV) ejection fraction (LVEF > 45%) who received RVA pacing had Doppler echocardiography performed at baseline and after one year follow up. At one year follow up, left atrial (LA) volumes (pre-atrial contraction volume and the minimal volume) and their indexes were significantly increased with reduction in passive emptying fraction and total emptying fraction (all p < 0.05). LA segmental tissue velocities - mean peak systolic (Sm-la), peak early diastolic (Em-la) and late diastolic (Am-la) - were also significantly reduced (all p < 0.001). A reduction of Am-la > 30% occurred in 24% of patients, and was more prevalent in patients with an elevation of LV filling pressure (E/e' > 15) at one year (44.1% vs. 11.7%, χ2 = 12.75, p < 0.001) as well as those with a reduction of LVEF ≥ 5% (34.0% vs. 14.3%, χ2 = 5.140, p = 0.023). By multivariate regression analysis, E/e' > 15 at one year (odds ratio [OR] 5.213; 95% confidence interval [CI] 1.778-15.281) and reduction of LVEF ≥ 5% (OR 3.181; 95% CI 1.045-9.686) were independent predictors of reduction of Am-la > 30%.ConclusionsChronic RVA pacing results in LA remodeling and reduced atrial function. This is related to elevated filling pressures and impairment of LV systolic function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 157, Issue 3, 14 June 2012, Pages 364-369
نویسندگان
, , , , , , , , ,