کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5983638 1578038 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparison of atenolol versus bisoprolol with noninvasive hemodynamic and pulse wave assessment
ترجمه فارسی عنوان
مقایسه آتنولول و بیزوپرولول با ارزیابی موج های همودینامیک و پالس غیر تهاجمی
کلمات کلیدی
بتا بلوکر کننده، فشار خون مرکزی، فشار خون، کارت مغناطیسی امپدانس،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های درون ریز و اتونومیک
چکیده انگلیسی


- Atenolol and bisoprolol are hemodynamically similar.
- Both drugs decreased diastolic but not systolic central blood pressure.
- Both drugs similarly induced bradycardia and increased stroke volume.
- Both drugs did not significantly alter arterial stiffness parameters.
- Both drugs similarly reduced systemic vascular resistance.

We aimed to compare atenolol versus bisoprolol regarding general hemodynamics, central-peripheral blood pressure (BP), pulse wave parameters, and arterial stiffness. In this open-label, crossover study, we recruited 19 hypertensives, untreated or with stable monotherapy. Patients were randomized to receive atenolol (25-50 mg) or bisoprolol (2.5-5 mg), and then switched medications after 4 weeks. Studies were performed at baseline and after each drug period. In pulse wave analyses, both drugs significantly increased augmentation index (P < .01) and ejection duration (P < .02), and reduced heart rate (P < .001), brachial systolic BP (P ≤ .01), brachial diastolic BP (P ≤ .001), and central diastolic BP (P ≤ .001), but not central systolic BP (P ≥ .06). Impedance cardiographic assessment showed a significantly increased stroke volume (P ≤ .02). There were no significant differences in the effects between drugs. In conclusion, atenolol and bisoprolol show similar hemodynamic characteristics. Failure to decrease central systolic BP results from bradycardia with increased stroke volume and an earlier reflected aortic wave.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society of Hypertension - Volume 9, Issue 5, May 2015, Pages 390-396
نویسندگان
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