کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5989769 1578613 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Denervation of gastroepiploic artery graft can reduce vasospasm
ترجمه فارسی عنوان
حفاظت از پیوند عروق گوارشنشده می تواند موجب بروز اسپاسم شود
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundThe right gastroepiploic artery is useful as an in situ arterial graft for coronary artery bypass grafting. However, the gastroepiploic artery is more likely to cause vasospasms compared with the internal thoracic artery. We hypothesized that the cause of the spasms is the stimulation of the periarterial sympathetic nerve, because the gastroepiploic artery is classified as a muscular artery. In this study, we examined whether the spasm is reduced by removing the periarterial sympathetic nerve.MethodsUnused parts of the gastroepiploic artery were obtained from patients who underwent coronary artery bypass grafting. The vessel was cut into 2 segments, and they were assigned to control (N+) and denervation (N−) groups. The periarterial nerve was microscopically removed from the vessels of the N− group. The vessels in both groups were investigated by hematoxylin-eosin or immunohistochemical staining, and they were stimulated by electrical field stimulation with serial frequency for isometric tension measurement.ResultsHistologic analyses revealed that periarterial connective tissues including neuropeptide Y were removed to expose the external elastic membrane in the N− vessel, whereas they were preserved in N+. The mean contraction by electrical field stimulation with serial frequency was consistently lower in N− than in N+ (P < .05 at 20 and 50 Hz; n = 8 each). Endothelium-dependent relaxation and contractile function of the smooth muscle were similar in both groups.ConclusionsThe removal of the periarterial sympathetic nerve from the human gastroepiploic artery reduced vascular contraction, elicited by peripheral nerve stimulation, without disturbing endothelial and smooth muscle contractile functions. This reduction may contribute to the prevention of vasospasms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Thoracic and Cardiovascular Surgery - Volume 147, Issue 3, March 2014, Pages 951-955
نویسندگان
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