کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5990491 | 1578637 | 2012 | 7 صفحه PDF | دانلود رایگان |

ObjectiveThe study objective was to determine whether the vasculopathy seen in nonobstructed lung regions in chronic thromboembolic pulmonary hypertension is induced by the local blood flow increase or by factors released by the ischemic lung.MethodsThree groups of 10 piglets were studied 5 weeks after right pulmonary artery ligation, right pneumonectomy, or right pulmonary artery dissection (sham). Pulmonary vascular resistance, pulmonary arterial vasoreactivity, and morphometry were measured, and gene expressions of factors involved in vascular smooth muscle cell proliferation were quantified.ResultsLeft lung blood flow was similarly increased after right pneumonectomy and right pulmonary artery ligation. Compared with right pneumonectomy, right pulmonary artery ligation resulted in left lung vasculopathy with increased pulmonary vascular resistance (PÂ =Â .0009), medial hypertrophy of the distal pulmonary artery (PÂ <Â .0001), and decreases in maximal relaxation to acetylcholine (PÂ =Â .013) and endothelial nitric oxide synthase gene expression (PÂ =Â .041). These values were similar after sham and right pneumonectomy. In the left lung, right pulmonary artery ligation increased the gene expressions for insulin-like growth factor (PÂ =Â .034), platelet-derived growth factor (PÂ =Â .0006), and vascular endothelial growth factor (PÂ =Â .0105) compared with right pneumonectomy and sham. Whereas endothelin-1 gene expression was not affected, expressions of endothelin-1 receptors A and B were downregulated after right pneumonectomy (PÂ =Â .048 and PÂ =Â .039, respectively) and right pulmonary artery ligation (PÂ =Â .033 and PÂ =Â .028, respectively).ConclusionsPulmonary vasculopathy was absent in the remaining lung 5 weeks after right pneumonectomy but developed in the nonobstructed lung regions 5 weeks after right pulmonary artery ligation, suggesting that factors released by the ischemic lung induced vascular remodeling in the contralateral lung. This endocrine process may involve the release of factors involved in vascular smooth muscle cell proliferation.
Journal: The Journal of Thoracic and Cardiovascular Surgery - Volume 143, Issue 4, April 2012, Pages 967-973