Maximal Oxygen Uptake-Risk Predictor of NSCLC Resection in Patients With Comorbid Emphysema: Lessons From NETT

We compared VO2 max values from ACCP Guidelines and from NETT's homogenous NULPD surrogate for predicting operative mortalities. Estimated mid and long-term non-cancer related survival in NETT's subset was also obtained. NETT and ACCP Guideline VO2 max values were similar in the “low” and “mid” risk operative mortality categories but NETT's “high” risk subset showed lower mortality (14% vs. 26%). Estimated non-cancer related survival in NETT ”low”, “mid” and “high” risk VO2 max categories at two and eight years were 100%, 74%, 59% and 48%, 26%, 14%, respectively. The lower predicted risk in NETT's “high- risk” subset raises the possibility of extending indications for potential curative resection in selected patients. The NETT surrogate also provides hitherto unavailable estimate on long-term non-cancer related survival after potential curative resection of NSCLC and suggests that the operation does not shorten eight-year longevity.