Rh(III)-catalyzed synthesis of (dihydro)quinolines via the annulation of N-sulfonyl 2-aminobenzaldehydes with olefins

We developed a new synthetic method for the production of 1,2-dihydroquinolines and quinolines via the Rh(III)-catalyzed annulation of N-sulfonyl 2-aminobenzaldehydes with olefins. Various functionalities were found to be compatible under the operationally simple conditions. This study provides the first example of a Rh(III)-catalyzed synthesis of 1,2-dihydroquinolines.

Graphical AbstractRh(III)-catalyzed annulation of N-sulfonyl 2-aminobenzaldehydes with olefins was accomplished and used for the synthesis of substituted (dihydro)quinolines.Figure optionsDownload as PowerPoint slide