کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6007656 1184953 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Somatosensory-evoked potential modulation by quadripulse transcranial magnetic stimulation in patients with benign myoclonus epilepsy
ترجمه فارسی عنوان
مدولاسیون پتانسیل پدیده سوماتوسنسوری با تحریک مغناطیسی مغز تراکرویال چهارگانه در بیماران مبتلا به صرع مایکوکلونوس خوش خیم
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- In healthy subjects, quadripulse transcranial magnetic stimulation (QPS) over the primary motor cortex (M1) induces bidirectional heterotopic plasticity in the somatosensory cortex (S1), following the Bienenstock-Cooper-Munro (BCM)-like theory.
- In patients with benign myoclonus epilepsy (ME patients), QPS over M1 induces long-term potentiation (LTP) but no long-term depression (LTD) in S1.
- QPS is not applicable to the treatment for ME patients because the frequency dependency may be completely different between the healthy subjects and the patients.

ObjectiveIn patients with benign myoclonus epilepsy (ME), giant sensory-evoked potential (SEP) reflects the hyperexcitability of the sensory cortex. The aim of this study was to compare the effect of quadripulse transcranial magnetic stimulation (QPS) on the median nerve SEP between ME patients and healthy subjects.MethodsTen healthy volunteers and six ME patients with giant SEP participated in this study. QPSs at interpulse intervals (IPIs) of 5, 30, 50, 100, 500 and 1250 ms were applied over the left primary motor cortex (M1) for 30 min. The peak-to-peak amplitudes of N20 to P25 (N20-P25) and P25 to N33 (P25-N33) components were measured at the left somatosensory cortex.ResultsIn healthy participants, the P25-N33 was bidirectionally modulated by QPS over M1, following the Bienenstock-Cooper-Munro (BCM) theory. The N20-P25 was not affected by any QPSs. In ME patients, the giant P25-N33 was potentiated after any QPSs. Furthermore, the N20-P25 was also potentiated after QPS at IPIs of 5, 30, 50 100 or 500 ms.ConclusionsIn ME patients, the cascade for long-term depression-like effects may be impaired.SignificanceThe giant SEP was furthermore enhanced by QPS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 127, Issue 2, February 2016, Pages 1560-1567
نویسندگان
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