کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6007662 1184953 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A signal-to-noise-ratio-based analysis of multifocal visual-evoked potentials in multiple sclerosis risk assessment
ترجمه فارسی عنوان
تجزیه و تحلیل مبتنی بر نسبت سیگنال به نویز از پتانسیل های تصویری چند فن آوری در ارزیابی ریسک ابتلا به مولتیپل اسکلروزیس
کلمات کلیدی
پتانسیل بصری مضر، نسبت سیگنال به نویز، عصب باصره، تابع ویژوال، مولتیپل اسکلروزیس، مقیاس وضعیت ناتوانی گسترده،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Assessment of MS patients' visual function was improved by using signal-to-noise ratio (SNR) values at ring 5.
- Multifocal visual-evoked potentials' (mfVEPs) SNR values decreased as risk of developing MS increased.
- MfVEPs' ring 5 eccentricity amplitude was related to disability severity in MS patients.

ObjectiveTo study the value of using the signal-to-noise ratio (SNR) of multifocal visual-evoked potentials (mfVEPs) in assessment of subjects at risk of developing multiple sclerosis (MS).MethodsMfVEP signals were obtained from 15 patients with radiologically isolated syndrome (RIS), from 28 patients with clinically isolated syndrome (CIS), from 28 with clinically definite MS and from 24 control subjects. The CIS and MS groups were divided into two subgroups: those with eyes affected by optic neuritis (ON) and those without (non-ON). The mfVEPs' SNR was obtained for both the whole visual field and at various eccentric rings. The area under the curve (AUC) was calculated by comparing the control subjects' mfVEP SNR values with those of the RIS, CIS and MS groups.ResultsIn whole visual field analysis, risk of developing MS increased as SNR decreased (SNRCONTROL = 0.70, SNRRIS = 0.62, SNRCIS-nonON = 0.54, SNRCIS-ON = 0.40, SNRMS-nonON = 0.52, SNRMS-ON = 0.40). Ring 5 (9.8°-15° eccentricity) was most affected by the SNR decrease, as indicated by its higher AUC values (AUCFULL_EYE = 0.81, AUCRING_5 = 0.89). A significant relationship (Spearman correlation, ρRING_5 = 0.61) between SNR values and disability severity on the Expanded Disability Status Scale (EDSS) was observed in clinically definite MS patients.ConclusionA new method based on analysis of the SNR of mfVEP signal amplitude improves assessment of patients at risk of developing MS.SignificanceImproved mfVEP assessment of MS-risk patients was achieved by using SNR values at 9.8°-15° eccentricity of the visual field.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 127, Issue 2, February 2016, Pages 1574-1580
نویسندگان
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