کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6007721 1184956 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anterior cingulate activity to monetary loss and basal ganglia activity to monetary gain uniquely contribute to the feedback negativity
ترجمه فارسی عنوان
فعالیت قارچی قدامی به از دست دادن پول و فعالیت های قاعدگی پایه به افزایش پول منحصرا به منفی بازخورد کمک می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- The feedback negativity is a composite of two signals: loss-related theta activity in the anterior cingulate cortex, and gain-related delta activity with a potential source in the striatum.
- Symptoms of internalizing psychopathology relate specifically to reduced gain-related delta activity and not loss-related theta activity.
- Gain-related delta activity may specifically be effective for quantifying impaired reward sensitivity and basal ganglia dysfunction in clinical populations.

ObjectiveThe feedback negativity (FN) is an event-related potential that differentiates unfavorable versus favorable outcomes. Although thought to reflect error-related activity within the anterior cingulate cortex, recent work indicates the FN may also reflect reward-related activity that has been linked to the basal ganglia. To date, it remains unclear how to reconcile these conflicting perspectives.MethodsWe decomposed the FN by applying time-frequency analysis to isolate activity unique to monetary losses and gains. The FN was recorded from 84 individuals during a laboratory gambling task.ResultsTwo signals contributed to the FN elicited by unpredictable outcomes: theta activity (4-7 Hz) was increased following monetary loss, and delta activity (<3 Hz) was increased following monetary gain. Predictable outcomes elicited delta but not theta activity. Source analysis revealed distinct generators, with loss-related theta localized to the anterior cingulate cortex and gain-related delta to a possible source in the striatum. Symptoms of depression, anxiety, and stress reactivity were specifically associated with blunted gain-related delta.ConclusionsThe FN may be a composite of loss- and gain-related neural activity, reflecting distinct facets of reward processing.SignificanceGain-related delta activity may provide unique information about reward dysfunction in major depression and other internalizing psychopathology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 126, Issue 7, July 2015, Pages 1338-1347
نویسندگان
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