کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6007984 1184960 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modulation of temporal summation threshold of the nociceptive withdrawal reflex by transcutaneous spinal direct current stimulation in humans
ترجمه فارسی عنوان
مدولاسیون آستانه جمعی زمانی رفلکس خروجی ناخوشایند با تحریک جریان مستقیم نخاعی پوستی در انسان
کلمات کلیدی
تحریک جریان مستقیم بین نخاعی، جمع بندی موقتی رفلکس خروج ناسازگار نورونهای دامنه وسیع،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Transcutaneous spinal direct currents (tsDCS) modulate the temporal processing of the nociceptive stimuli at spinal level.
- tsDCS could inhibit the transitory frequency-dependent facilitation of the spinal wide dynamic range neurons activity at the basis of temporal summation of pain.
- As future perspective, modulation of temporal processing of nociceptive stimuli by tsDCS could be helpful in pain treatment as well as in preventing pain becoming chronic.

ObjectiveTranscutaneous spinal direct current stimulation (tsDCS) modulates spinal cord pain pathways. The study is aimed to clarify the neurophysiology of the tsDCS-induced modulation of the spinal cord pain processing by evaluating the effect of the tsDCS on temporal summation threshold (TST) of the nociceptive withdrawal reflex (NWR).MethodsIn a randomized, double-blind, crossover study the effects of anodal, cathodal and sham tsDCS (2 mA, 15 min) applied on the skin overlying the thoracic spinal cord were investigated in 10 healthy subjects.ResultsAnodal tsDCS induced a long-lasting (up to 60 min) increase in TST of the NWR as well as a parallel decrease in related psychophysical temporal summation of pain, while cathodal and sham tsDCS resulted ineffective.ConclusionsAnodal tsDCS represents a non-invasive tool able to induce an early and long-lasting depression of the transitory facilitation of the wide dynamic range neurons activity at the basis of both the temporal summation of the NWR and the related temporal summation of pain sensation.SignificanceThe modulation of the temporal processing of nociceptive stimuli could be effective in treating clinical pain conditions in which pain is generated by spinal cord structures.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 127, Issue 1, January 2016, Pages 755-761
نویسندگان
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