3-A-D-2-17. Correlation between cerebrospinal fluid biomarkers of Alzheimer's disease and EEG activities assessed by eLORETA (exact Low Resolution Electromagnetic Tomography)

The logarithmic values of CSD of the right temporal area in theta band (4-8 Hz) were negatively correlated with the concentration of Aβ42 (p < 0.05). In addition, the value of LPS between the left frontal eye field and the right auditory area in alpha 2 band (10-13 Hz) were also negatively correlated with the concentration of T-tau (p < 0.05). These EEG characteristics could be related with the disturbances of cholinergic nerves and axonal projections, respectively. In this study, Aβ42 of CSF was associated with CSD of EEG, likewise, T-tau was relevant to LPS of EEG. The prediction for CSF biomarkers based on EEG parameters could be helpful for early diagnosis of AD.