Limb segment load inhibits post activation depression of soleus H-reflex in humans

► Limb segment load resulted in a predominant inhibition of post activation depression in humans, but minimally modulated the response in a subject with SCI. ► The inhibition of post activation depression was directly related to the magnitude of the limb segment load. ► These findings highlight whether limb load can influence spinal neuronal reorganization from the acute to the chronic state after SCI.